Lasers for Optogenetics & Neuroscience & Gene Sequencing
 

Optogenetics is a booming multidisciplinary bioengineering technology. It has the characteristic of high spatial-temporal resolution and cell-type specific. It overcomes the disadvantages of traditional methods of the activity control for the cell and organism, and also provides a method for the research of neuroscience. The research fields include fundamental research of neural circuit, study and memory research, habituation research, dyskinesia, sleep disorders, parkinsonism, depressive disorder, anxiety disorder etc., and many classic laboratory animal germ line (drosophila melanogaster, nemathelminth, mice, Marmoset, and machin etc.).


Neuroscience is the scientific study of the nervous system. It is currently an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics, medicine, genetics, and allied disciplines including philosophy, physics, and psychology. It also exerts influence on other fields, such as neuroinduction and neurology. The scope of neuroscience has broadened to include different approaches used to study the molecular, cellular, developmental, structural, functional, evolutionary, computational, and medical aspects of the nervous system.

 

Gene sequencing refers to the analysis of specific DNA fragment base sequence to obtain biological genetic information. As one of the most important biological analysis methods, DNA sequencing not only provides important data for basic biological research such as genetic information disclosure and gene expression regulation, but also plays an important role in applied research such as gene diagnosis and gene therapy.

 

Changchun New Industries (CNI) founded in 1996, is a manufacturer of solid-state and diode laser systems. CNI laser features with high performance, nice reliability, and specifically designed for OEM, scientific, industrial and instrumentation use. In addition, CNI lasers are ISO-9001, FDA, CE, RoHS and JQA certified. CNI can provide different lasers for Optogenetics with free space and pigtailed versions. Also the accessories used for Optogenetics are available for a total solution from customers.
 

 Features

  ■ CNI provided high reliability lasers
■ All the necessary accessories can be provided
■ Easy to install and maintain
■ Customized solution can be provided upon request
 Related Lasers
 
Ultraviolet lasers (nm): 266  351  355  360  375
Blue lasers (nm): 405  435  442  445  447  457 nm  460  465  473  488  491
Green lasers (nm): 515  520  532  543  556  561
Yellow lasers (nm): 589  593
Red lasers (nm): 633  637  640  642  650  671  690  720  750
Infrared lasers (nm): 785  800  808  825  830  905  915  940  980  1064  1342  1990  2200
Multi-wavelength lasers (nm): Blue/ green/ yellow/ red
 
 ■ Waveform Editable Laser Light Source
 

CNI developed the laser light source with freely edited waveform. The model is fiber coupled with high stability, easy for operation. It can be used in optogenetics, biomedical and other applications that require laser modulation output.

In traditional optogenetics system construction, the experimental system is complicated to set up, the conditions cannot be precisely controlled and the maintenance of the experimental system is difficult.

This new model integrates the self-developed ultra-stable laser light source, high-precision light source control system, intelligent human-computer interaction interface, human eye safety protection and other functions, which greatly simplifies the construction difficulty of optogenetics system.

  •  

    • ◆ Integrated system with lasers controller

  • ◆ Intelligent human-computer interface

  • ◆ Fiber interface docking detection,

  •      human eye protect

  • ◆ High power stability<0.5%

  • ◆ Support external trigger signal

     

◆ Waveform editable

◆ Synchronizing signal output

◆ USB port for program update and reading data

◆ Single or dual wavelength customized

◆ Wavelength customized

◆ Angleadjustable, easy for experimental
 

Power variable range

0-100mW

Power adjustable step

0.1mW

Fall time

1ms-3600s/DC

Rise time

1ms-3600s/DC

Power stability

<0.5% (4h rms)

Available

465nm、473nm、589nm、594nm(customized upon request)

Connector type

SMA905

Synchronizing signal port

BNC

External signal port (Trigger)

BNC

Custom signal input port (Input)

BNC

Warm-up time

5min

Dimension (mm)

252×240×141.5 (L×W×H)

Laser light source quantity

Single/ dual (customized upon request)

Datasheet

 
Accessories
Research achievements of CNI laser for Optogenetics from customers

 (1) Optogenetic stimulation of a hippocampal engram activates fear memory recall
(Nature, 484(7394): 381–385. doi:10.1038/nature11028) (CNI-473nm)

 (2) Ultrahigh accuracy imaging modality for super-localization microscopy
(Nature Methods, VOL.10,2013,335) (CNI-635nm and 488nm)

 (3) Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task
(ORIGINALRESEARCH doi: 10.3389/fnbeh.2015.00286) (CNI-589nm)

 (4) Optogenetic Evidence That Pallidal Projections, Not Nigral Projections, from the Nucleus Accumbens Core Are Necessary
for Reinstating Cocaine Seeking (The Journal of Neuroscience, 2013•33(34):13654–13662) (CNI-561nm)

 (5) Control of a specific motor program by a small brain area in zebrafish
(Front Neural Circuits, 2013; 7: 67) (CNI-405nm and 457nm)

 (6) Fatal Neurological Respiratory Insufficiency Is Common Among Viral Encephalitides (Oxford Journals, 2013:208) (CNI-470nm)

 (7) Temperature-dependent Activation of Neurons by Continuous Near-infrared Laser
(Cell Biochemistry and Biophysics,vol.53, 33-42,2009)(CNI-1064nm)

 (8) Distal connectivity causes summation and division across mouse visual cortex (Nature Neuroscience, 2014,Volume:17,Pages:

      30–32) (CNI-473nm)

(9) Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers
(PNAS,2012,109(22),8483-8488) (CNI-980nm)


(10) Viral Vector-Based Techniques for Optogenetic Modulation In Vivo
(Viral Vector Approaches in Neurobiology and Brain Diseases Neuromethods, Volume 82, 2014, pp 289-310) (CNI-447nm)

 (11) Optogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced Reinstatement of Palatable Food Seeking in
Female Rats (The Journal of Neuroscience, 2013, 33(1):214–226) (CNI-593.5nm)

 (12) Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens
(The Journal of Neuroscience, 2010, 30(20):7105-7110) (CNI-453nm)

 (13) Firing of Hippocampal Neurogliaform Cells Induces Suppression of Synaptic Inhibition
(The Journal of Neuroscience, 2014•34(4):1280–1292) (CNI-532nm)

 (14) Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties
(Oxford Journals, Volume 23,Issue 8,1965-1977) (CNI-473nm)

 (15) Au–PLA nanocomposites for photothermally controlled drug delivery (J. Mater. Chem. B, 2014,2, 409-417)(CNI-808nm)

 (16) Synthesis of magnetic, fluorescent and mesoporous core-shell-structured nanoparticles for imaging, targeting and photodynamic
therapy (J. Mater. Chem., 2011,21, 11244-11252)(CNI-660nm)

 (17) Asphaltene Adsorption onto an Iron Surface: Combined Near-Infrared (NIR), Raman, and AFM Study of the Kinetics,
Thermodynamics and Layer Structure (Energy Fuels,2011,25(1), pp 189–196)(CNI-633nm)

 (18) The electrophysiological properties of voltage-gated potassium channels on cultivated porcine retinal ganglion cells irradiated with
continuous near-infrared laser (Chinese journal of ophthalmology 02/2012; 48(2):153-8).(CNI-845nm)

 (19) High-resolution simultaneous voltage and Ca2+imaging (J Physiol February 1, 2011.589(3)489-494)(CNI-543nm)
Keep in touch with us

Contact us sales@eforcelaser.com.au